2024-03-28T13:13:27Zhttp://oai.recercat.cat/request
oai:recercat.cat:2072/2476762015-03-12T23:17:50Zhdl_2072_179329 am 3u dcA long-standing question in evolutionary biology is what defines a species. The biological species concept considers a species as a population of individuals that interbreeds freely and produces viable offspring. Therefore, reproductive isolation is the essence of species. Hybrid necrosis is one form of post-zygotic reproductive isolation. In this chapter, we summarize what is known to date about this phenomenon and highlight progress made in the understanding of these immune-triggered hybrid incompatibilities through our research in the plant model Arabidopsis thaliana.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704http://hdl.handle.net/2445/63971engArabidopsis thalianaBiologia molecular vegetalFisiologia vegetalPlant molecular biologyPlant physiologyThe evolution of post-zygotic isolation barriers by immune-triggered hybrid incompatibilities in Arabidopsis thaliana
oai:recercat.cat:2072/2479182015-03-19T23:13:07Zhdl_2072_179329 am 3u dcOrganic food products are highly susceptible to fraud. Currently, administrative controls are conducted to detect fraud, but having an analytical tool able to verify the organic identity of food would be very supportive. The state-of-the-art in food authentication relies on fingerprinting approaches that find characteristic analytical patterns to unequivocally identify authentic products. While wide research on authentication has been conducted for other commodities, the authentication of organic chicken products is still in its infancy. Challenges include finding fingerprints to discriminate organic from conventional products, and recruiting sample sets that cover natural variability. Future research might be oriented towards developing new authentication models for organic feed, eggs and chicken meat, keeping models updated and implementing them into regulations. Meanwhile, these models might be very supportive to the administrative controls directing inspections towards suspicious fraudulent samples.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704http://hdl.handle.net/2445/64324engAliments naturalsPollastreInspecció dels alimentsNatural foodsChickenFood inspectionOrganic chicken product authentication: state-of-the-art and future perspectives
oai:recercat.cat:2072/2480012015-03-20T23:12:09Zhdl_2072_179329 am 3u dcA multicompartment compliance aid (MCA) is a blister-type repackaging system that aims to facilitate drug administration and thereby increase patient adherence. One of the characteristics of the MCA that should be taken into account is the moisture permeability, since this atmospheric condition is one of the most important factors that can modify the stability of medicines. In the current paper we report the moisture permeability tests performed on a MCA according to the US Pharmacopeia. This information on the suitability of the device will help pharmacists implement a high-quality professional service.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704http://hdl.handle.net/2445/64366engEnvasament dels medicamentsAdministració de medicamentsEstabilitat dels medicamentsServeis farmacèuticsDrugs packagingAdministration of drugsDrug stabilityPharmaceutical servicesDegree of hermeticity of a multicompartment compliance aid: Implications for the quality of professional pharmaceutical services
oai:recercat.cat:2072/2480032015-03-20T23:12:12Zhdl_2072_179329 am 3u dcGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) is considered a housekeeping protein that is present in virtually all organisms, where it performs metabolic functions essential for survival. GAPDH plays an essential role in the process of energy production, and is also involved in numerous biological processes. GAPDH belongs to a subset of proteins called moonlighting proteins, in which different functions are associated with a single polypeptide chain. The multifunctionality of GAPDH has been described in pathogenic and probiotic microorganisms, in mammals and in plants. In this review, we summarize the moonlighting role of GAPDH in bacteria.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704http://hdl.handle.net/2445/64368engOxidoreductasesBacterisBioquímicaOxidoreductasesBacteriaBiochemistryGlyceraldehyde-3-phosphate dehydrogenase as a moonlighting protein in bacteria
oai:recercat.cat:2072/2552712015-10-29T23:26:58Zhdl_2072_179329 am 3u dcHuman health risk assessment is the basis for groundwatercontamination and remediation goals definitions. Chlorinated solventshave a high toxicity for humans, even at low concentrations, and areimportant soil and groundwater pollutants. The main objective of thiswork is to assess the human health risk derived of exposition to acontaminated groundwater using a commercial Risk Analysis model(RBCA) and taking into consideration different exposure factors. Acase study was used. Some risk differences were observed usingspecific exposure factors in different countries, which were explainedby differences in life style.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67541engCompostos organocloratsContaminació de l'aiguaAvaluació del risc per la salutHigiène ambientalOrganochlorine compoundsWater pollutionHealth risk assessmentEnvironmental healthDetailed human risk assessment arising from groundwater contaminated by chlorinated hydrocarbons (DNAPLs)
oai:recercat.cat:2072/2552722015-10-29T23:27:00Zhdl_2072_179329 am 3u dcPlant cell and organ cultures constitute a promisingplatform for the production of numerous valuable secondarycompounds. Currently, in vitro culture techniques involve bothempirical and rational approaches as suitable strategies to conditionhigh metabolite production and establish competitive plant cell-basedbioprocesses. In this context, we have developed hairy root cultures ofPanax ginseng, and engineered hairy root cultures of Duboisia,Datura metel and Hyoscyamus spp and plant cell cultures of Centellaasiatica and Taxus spp. This chapter describes our work on thedevelopment of two different biotechnological systems to improvetaxol production in cell suspension cultures of Taxus spp andginsenoside production in hairy root cultures of Panax ginseng.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67542engCultiu de cèl·lules i teixits vegetalsFitoquímicaFisiologia vegetalPlant cell and tissue cultureBotanical chemistryPlant physiologyPlant cell and organ cultures as a source of phytochemicals
oai:recercat.cat:2072/2552732015-10-29T23:27:00Zhdl_2072_179329 am 3u dcADHD (Attention Deficit and Hyperactive Disorder) is the most common neurobehavioral disorder of childhood, presenting with pervasive and impairing symptoms of inattention, hyperactivity, impulsivity, or a combination. There is scientific evidence that some dietary and physical activity strategies may be useful to improve the symptoms of ADHD and benefit the social, cognitive and academic performance of children and adolescents with ADHD. The purpose of our study was to review the scientific literature on the role of diet and physical activity in ADHD symptomatology up to date.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67543engTrastorns per dèficit d'atenció amb hiperactivitat en els infantsDietoteràpiaExerciciNutricióAttention deficit disorder with hyperactivity in childrenDiet therapyExerciseNutritionThe role of diet and physical activity in children and adolescents with ADHD
oai:recercat.cat:2072/2552872015-10-30T23:21:53Zhdl_2072_179329 am 3u dcThe diversification of Cheirolophus in Macaronesian archipelagos constitutes a paradigmatic example of radiation on oceanic islands. Phylogenetic and molecular dating analyses indicate an extraordinarily fast process, showing one of the highest speciation rates ever found on plants from oceanic islands. Such radiation has been recently studied employing phylogeographic, population genetic and molecular cytogenetic approaches. Here, the main potential patterns and processes involved in the diversification of the genus in the Canary Islands and Madeira are reviewed and discussed as a whole.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67557engCompostesMacaronèsiaFilogènia (Botànica)FilogeografiaCitogenèticaBotànicaCompositaeMacaronesiaPhylogeny (Botany)PhylogeographyCytogeneticsBotanyMolecular insights into the diversification of Cheirolophus (Asteraceae) in Macaronesia
oai:recercat.cat:2072/2552882015-10-30T23:21:56Zhdl_2072_179329 am 3u dcThe usefulness of the ultrastructural characters of spermiogenesis and of the spermatozoon in the interpretation of relationships in the Platyhelminthes has been widely demonstrated. The present paper provides a review and an update on the ultrastructural knowledge on spermiogenesis and on the spermatozoon in cyclophyllidean cestodes. For each family of cyclophyllideans the pattern of spermiogenesis and the type of sperm cell is provided. Moreover, the most interesting characteristics of both spermiogenesis and the spermatozoon are compiled and illustrated for each family. Finally, new spermatological data on some species of the Anoplocephalidae and the Taeniidae are provided.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67558engEspermatogènesiEspermatozoidesCestodesUltraestructura (Biologia)ParasitologiaSpermatogenesisSpermatozoaTapewormsUltrastructure (Biology)ParasitologyUltrastructure of spermiogenesis and the spermatozoon in cyclophyllidean cestodes
oai:recercat.cat:2072/2552912015-10-30T23:22:00Zhdl_2072_179329 am 3u dcOxylipins are a family of natural compounds that are reported to perform a variety of biological functions. Besides the biological properties of such compounds, interest in hydroxy fatty acids is increasing, due to the industrial applications of these renewable compounds as a starting material for resins, emulsifiers, plastics or polyesters. Hydroxy fatty acids are used as thickeners in a new generation of emulsifiers and lubricants, to reach new levels of performance. When grown in submerged culture with oleic or linoleic acid, Pseudomonas aeruginosa 42A2 produced several oxylipins. In this study, oxylipin production and its applications are examined.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67563engProductes naturalsPseudomonasMicrobiologiaNatural productsPseudomonasMicrobiologyProduction of bacterial oxylipins by Pseudomonas aeruginosa 42A2
oai:recercat.cat:2072/2551642015-11-02T23:14:08Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67431engEsfingolípidsQuímica orgànicaSphingolipidsOrganic chemistryChemical approaches to sphingolipid research
oai:recercat.cat:2072/2552922015-11-02T23:14:10Zhdl_2072_179329 am 3u dcDiabetic cardiomyopathy is characterized by structural and functional alterations in the heart muscle of people with diabetes that finally lead to heart failure. Metabolic disturbances characterized by increased lipid oxidation, intramyocardial triglyceride accumulation and reduced glucose utilization have all been involved in the pathogenesis of diabetic cardiomyopathy. On the other hand, evidences arisen in the recent years point to a potential link between chronic low-grade inflammation in the heart and metabolic dysregulation. Interestingly, the progression of heart failure and cardiac hypertrophy usually entails the activation of pro-inflammatory pathways. Therefore, in this chapter we summarize novel insights into the crosstalk between inflammatory processes and metabolic dysregulation in the failing heart during diabetes.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430http://hdl.handle.net/2445/67564engComplicacions de la diabetisMiocardiopatiesFarmacologiaDiabetes complicationsMyocardiopathiesPharmacologyInflammation and metabolic dysregulation in diabetic cardiomyopathy
oai:recercat.cat:2072/2021632016-03-04T08:28:37Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32393The preparation of enantiomerically pure compounds (EPC) is a continuous social demand due to the clinical advantages that enantiopure drugs offer over the racemic forms. Here, the best
well-established synthetic strategies to access to single-enantiomer compounds are briefly described and compared. In particular, the enantioselective catalysis is introduced paying special attention to the organocatalysis, an emerging and fruitful area in the EPCsynthesis.
Of particular interest is the use of small organic molecules as catalysts in cascade reactions. Organocascade reactions involve the formation of several chemical bonds and
often generate stereogenic centers with excellent stereoselectivity. Such one-pot reactions avoid time-consuming and costly step-bystep
processes and are environmentally friendly as they occur in the absence of metals. Additionally, the chemical waste of the
organocatytic cascade reactions is drastically reduced since the intermediates are not isolated and purified.http://hdl.handle.net/2445/32194engFarmacologiaEnantiòmersMedicamentsPharmacologyEnantiomersDrugsStrategies for the synthesis of enantiopure compounds focused on organocatalysis
oai:recercat.cat:2072/1795322016-03-15T23:50:26Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32392During the last years, our emphasis has focused in the study of the neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH) on central nervous system and their pharmacological prevention. In the process of this research, we have used a semipurified synaptosomal preparation from striatum of mice or rats as a reliable in vitro model to study reactive oxygen species (ROS) production by these amphetamine derivatives, which is well correlated with their dopaminergic injury in in vivo models. Using this preparation we have demonstrated that blockade of alpha7 nicotinic receptors with methyllycaconitine (MLA) and memantine (MEM) prevents ROS production induced by MDMA and METH. Studies at molecular level showed that both, MDMA and METH, displaced competitively the binding of radioligands for homomeric alpha7 and heteromeric nAChRs, indicating that they can directly interact with them. In all the cases MDMA displayed higher affinity than METH and it was higher for heteromeric than for alpha7 subtype. Preincubation of differentiated PC12 cells with MDMA or METH induces nicotinic acetylcholine receptors (nAChR) up-regulation in a concentration- and time-dependent manner, as many nicotinic ligands do, supporting their functional interaction with nAChRs. Such interaction expands the pharmacological profile of amphetamines and can account for some of their effects.http://hdl.handle.net/2445/21373engReceptors nicotínicsAmfetaminesNicotinic receptorsAmphetaminesInvolvement of nicotinic receptors in methamphetamine and MDMA induced neurotoxicity: Pharmacological studies
oai:recercat.cat:2072/2476542016-04-28T22:52:39Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/63704Global changes in dietary habits in the last decades caused an increase of added sugar consumption all over the world, which has been linked to the increasing prevalence of obesity, dyslipidemia, insulin resistance and cardiovascular disease. Fructose is widely used as a sweetener in the food and beverage industry, either as an integrant of the sucrose molecule or as a component of high fructose corn syrups. The consumption of fructose in beverages is especially dangerous, as the process of energy compensation by reduction in the ingestion of other foods does not work equally well with liquid than solid foods. Besides, fructose is the carbohydrate with the highest ability to induce hypertriglyceridemia, due to a marked increase in lipogenesis compared with glucose. In this review we will discuss some of the most recent studies performed in animal models and in humans to investigate the effects of excessive fructose consumption.http://hdl.handle.net/2445/63891engFructosaTrastorns del metabolismeModels animals en la investigacióFructoseDisorders of metabolismAnimal models in researchFructose effects on human health: Molecular insights from experimental models
oai:recercat.cat:2072/2678272016-11-08T23:33:21Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Polyphenols are a large and heterogeneous group of compounds widely distributed in fruits, vegetables, cereals and their products such as coffee or wine. These bioactive compounds can ameliorate our health by improving certain risk factors, especially the cardiovascular ones. Thus, many investigations have focused on the effects of some polyphenols and polyphenol-rich foods on cardiovascular and other chronic diseases.http://hdl.handle.net/2445/103448engPolifenolsMalalties cardiovascularsPolyphenolsCardiovascular diseasesBenefits of polyphenol intake on the cardiovascular risk parameter
oai:recercat.cat:2072/2680482016-11-25T23:50:08Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Lipopeptides such as lichenysin are biosurfactants of great interest, due to the demand for natural surface-active agents with low toxicity. Bacillus licheniformis AL 1.1 produces a lipopeptide characterized as lichenysin (LchAL1.1), which acts as a powerful surfactant, able to reduce surface tension to 28.5 mN m-1 and with a critical micelle concentration of 15 mg L-1. LchAL1.1 is particularly effective in preventing biofilm formation by pathogenic strains, has an emulsifying capacity and permeabilizes membranes by a colloid-osmotic process. The production of lipopeptides from agro-industrial residues, particularly molasses, is a sustainable process of great potential for the development of economic bioprocesses.http://hdl.handle.net/2445/104173engAgents tensioactiusSurface active agentsLichenysin production and application in the pharmaceutical field
oai:recercat.cat:2072/2680492016-11-25T23:50:10Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Helicobacter pylori is one of the human pathogens with highest prevalence around the world. Colonizing the human stomach, H. pylori could lead to peptic ulceration, gastric adenocarcinoma and gastric lymphoma. H. pylori is a genetically diverse bacterial species, and variability in virulence factors has a role in bacterial pathogenesis and progression to gastric cancer, although bacterium and host factors of progression are not completely understood. In a recent study, we have demonstrated that six housekeeping genes related to H. pylori pathogenesis were specifically amplified for H. pylori in a total of 52 H. pylori clones isolated from 11 patients. Although most clones isolated from the same patient showed identical gene sequences, events of multiple infection and microevolution were detected. We consider that housekeeping genes could be useful for H. pylori detection and to elucidate the mode of transmission and the relevance of the multiple infection. Further genetic studies are required to provide powerful tools to face all current unmet challenges of H. pylori infection, such as the elucidation of mode of transmission, the development of new sensitive and specific PCR methods for H. pylori detection, and implication of H. pylori in other diseases.http://hdl.handle.net/2445/104174engHelicobacteri pilòricGenètica bacterianaCàncerAparell digestiuHelicobacter pyloriBacterial geneticsCancerDigestive organsAdvances in the research of new genetic markers for the detection of Helicobacter pylori infection
oai:recercat.cat:2072/2680502016-12-01T01:26:40Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Data on leishmaniosis and its vectors (sand flies) in the Balearic Islands are scarce and restricted mainly to Majorca. According to the official data, the overall rate of human leishmaniosis (HL) is 0.7-3.5 cases per year/100,000 inhabitants (for the period 2001-2015), and the reported prevalence of canine leishmaniosis (CanL) varies between 0 and 45%, depending on the island and the dog population tested. In the present study, we investigated the sand fly fauna and current status of CanL in the Balearic Islands. Four sand fly species were captured: Phlebotomus perniciosus, a known vector in the Mediterranean area, P. sergenti, P. papatasi and Sergentomyia minuta. P. perniciosus was found throughout the island of Majorca, from sea level to the mountains, being detected in 70% of the capture sites and with a density of 6.7 specimens/m2. The global density of P. perniciosus in Minorca was of 3.4 specimens/m2, which constitutes a significant decrease compared to the results of a previous study performed 20 years ago. The influence of environmental factors on the presence or density of P. perniciosus differed according to the physiography of the area studied. A standard questionnaire sent to the local veterinarians in the Balearic Islands revealed that 73.8% of veterinarians had confirmed CanL cases in the previous 12 months and thought the disease was increasing in Minorca. The global seroprevalence of CanL in Minorca was 24%, being 31% among animals who had never left the island, which shows the existence of an autochthonous focus of CanL unrelated with an increasing vector density.http://hdl.handle.net/2445/104176engLeishmaniosiIlles BalearsLeishmaniasisBalearic IslandsCurrent status of Leishmaniosis in the Balearic Islands
oai:recercat.cat:2072/2552742017-10-12T05:34:42Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/67430The zebrafish embryo has emerged as promising
alternative
model for traditional in vivo developmental toxicological
screening due to their advantageous characteristics as their small size
and transparency. In this paper, we reviewed the applicability of the
zebrafish embryo model in some relevant areas to human t
oxicology
as developmental toxicity, cardiovascular toxicity and neurotoxicity
(behavioral assessment). Despite the promising results, further
optimization and testing of more substances as well as a harmonized
methodology is needed to streamline the metho
ds and make the assay
conducive to medium
-
throughput.http://hdl.handle.net/2445/67544engPeix zebraToxicologiaZebra fishToxicologyZebrafish as a model for developmental toxicity assessment
oai:recercat.cat:2072/2678742017-10-12T05:34:43Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Triclabendazole (TCBZ) is a veterinary drug used against Fasciola hepatica in cattle. The Cajamarca Valley in Peru is an endemic area of fascioliasis with a high infection rate in animals producing milk for human consumption. The administration of TCBZ during the lactating period can lead to TCBZ derivative residues in milk and cheese entering the human food chain. Milk-derivatives from treated animals have been found positive for TCBZ metabolites. One of these metabolites, triclabendazole sulfoxide
(TCBZSO), is embryolethal during early developmental stages in vitro in mouse
and zebrafish. In this study, we have calculated the estimated daily intake (EDI) of
TCBZSO due to milk and cheese consumption among a rural population in
Cajamarca in order to evaluate the associated risk for human embryonic
development. Although the expected maximum plasma concentration of TCBZSO
after a worst-case scenario simulation would be below the reported lowest
observed adverse effect concentration (LOAEC) for embryolethality in vitro
(10 μM), several limitations on the available information for exposure,
bioavailability and interspecies differences still impede the accomplishment of an
accurate risk assessment.http://hdl.handle.net/2445/103571engEmbriologiaCadenes alimentàries (Ecologia)Toxicitat dels medicamentsPerúEmbryologyFood chains (Ecology)Drug toxicityPeruRisk assessment for human embryonic development of triclabendazole residues in milk and cheese in the diet of a rural population in Cajamarca (Peru): A preliminary approach
oai:recercat.cat:2072/3067742018-03-16T06:33:16Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120781engPlantes ornamentalsAmaril·lidàciesCompostos bioactiusOrnamental plantsAmaryllidaceaeBioactive compoundsResearch in natural products: Amaryllidaceae ornamental plants as sources of bioactive compounds
oai:recercat.cat:2072/3067752018-03-16T06:33:16Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120784engBacterisMicroscòpia electrònicaTomografiaBacteriaElectron microscopyTomographyDeciphering the stack, a novel bacterial structure, by (cryo-) transmission electron microscopy and (cryo-) electron tomography
oai:recercat.cat:2072/3067102018-03-20T06:35:13Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120724engEtnobotànicaPlantes medicinalsAliments funcionalsEthnobotanyMedicinal plantsFunctional foodsMedicinal and food plants in ethnobotany and ethnopharmacology: Folk functional foods in Catalonia (Iberian Peninsula)
oai:recercat.cat:2072/3067712018-03-20T06:35:14Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120771engProbiòticsLlet maternaImmunologiaProbioticsBreast milkImmunologyImmunomodulatory role of probiotics in early life
oai:recercat.cat:2072/3067732018-03-20T06:35:15Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120773engPurinesNucleòtidsTeràpia genèticaPurinesNucleotidesGene therapyPolypurine Reverse Hoogsteen Hairpins as a tool for gene repair and editing
oai:recercat.cat:2072/3067762018-03-20T06:35:16Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120803engParasitologia mèdicaGastròpodesAntihelmínticsMedical parasitologyGastropodsAnthelminticsDevelopment of a strategy for the administration of praziquantel to the terrestrial edible snail Cornu aspersum parasitized by Brachylaima sp. metacercariae
oai:recercat.cat:2072/3068562018-04-28T05:35:57Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120878engInfluenzavirusDianes farmacològiquesQuímica farmacèuticaInfluenza virusesDrug targetingPharmaceutical chemistryFighting the Influenza A virus. New scaffolds and therapeutic targets
oai:recercat.cat:2072/1795312020-02-14T15:06:18Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32392Influenza is a highly contagious, major respiratory tract disease affecting millions of people each year. At present, two classes of antivirals are available: the neuraminidase inhibitors and the M2 proton channel blockers amantadine and rimantadine. However, rapid emergence of M2 blockers resistance makes imperative the development of new anti-influenza drugs. In the last few years several groups have synthesized and evaluated several analogs of amantadine. While several of them are active against wild-type M2 channel only a few are able to inhibit the mutant ion channels that lead to amantadine-resistance.http://hdl.handle.net/2445/21371engInfluenzavirusResistència als medicamentsInhibidors enzimàticsInfluenza virusesDrug resistanceEnzyme inhibitorsInhibitors of the M2 channel of influenza A virus
oai:recercat.cat:2072/3067092020-02-14T15:06:19Zhdl_2072_179329 am 3u dcThe E-book series Recent Advances in Pharmaceutical Sciences reports research contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences. This seventh volume consists of nine chapters, mainly dealing with the fields of botany, physiology, food
science, biochemistry & molecular biology, plant physiology, microbiology, parasitology, pharmacology, and medicinal chemistry.http://hdl.handle.net/2445/120717engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences VII
oai:recercat.cat:2072/3544272020-02-14T15:06:20Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/120717http://hdl.handle.net/2445/120877engMalaltia d'AlzheimerMedicamentsAlzheimer's diseaseDrugsStrategies against β-amyloid protein as therapeutics in Alzheimer's disease
oai:recercat.cat:2072/3491952020-02-14T15:06:20Zhdl_2072_179329 am 3u dcThis E-book is the eighth volume of a series that compiles contributions
from different areas of the multidisciplinary field of Pharmaceutical
Sciences. The E-book consists of 7 chapters that cover the areas of
organic chemistry, health and environmental management, plant
physiology, food science, toxicology, botany, parasitology, physiology,
biochemistry and molecular biology, microbiology, and pharmacology.http://hdl.handle.net/2445/128014engInvestigació farmacèuticaPharmaceutical researchRecent Advances in Pharmaceutical Sciences VIII
oai:recercat.cat:2072/3491962020-02-14T15:06:21Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/128014Magnetic nanoparticles have proven to be promising theranostic agents, namely tools for therapy and diagnosis. Among them, superparamagnetic iron oxide nanoparticles (SPIONs) highlight for their biocompatibility and reduced toxicity. Here, we describe the synthesis and characterization of SPIONs by co-precipitation of ferric and ferrous salts under mild conditions. These particles were able to accumulate in inflamed areas fact that was increased upon the application of an external magnetic field. Resonance magnetic imaging studies have shown their suitability as negative contrast agents for diagnosis. In addition, hybrid nanoparticles were obtained by incorporating the above described SPIONs into liposomes or nanoemulsions. The findings have confirmed the high potential of these systems for biomedical applications.http://hdl.handle.net/2445/128030engNanopartículesMagnetismeDiagnòsticTerapèuticaNanoparticlesMagnetismDiagnosisTherapeuticsMagnetic nanoparticles: From diagnosis to therapy
oai:recercat.cat:2072/3497222020-02-14T15:06:22Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/128014Alzheimer’s disease (AD) is the main neurodegenerative disorder worldwide. Its pathogenesis involves a network where various mechanisms are interconnected. This complex pathological network makes it extremely challenging to find an efficacious treatment. Herein, we give an overview on the design of the so-called multi-target-directed ligands, i.e. compounds that concurrently hit several key pathogenic factors within the network, as a realistic option to tackle AD, with a particular emphasis on some structural classes of multitarget hybrids recently developed in our group.http://hdl.handle.net/2445/128109engDesenvolupament de medicamentsMalaltia d'AlzheimerQuímica farmacèuticaDrug developmentAlzheimer's diseasePharmaceutical chemistryDevelopment of hybrid compounds to tackle Alzheimer’s disease
oai:recercat.cat:2072/3497232020-02-14T15:06:22Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/128014Numerous strategies have been proposed to overcome the blood-brain barrier (BBB) and efficiently deliver therapeutic agents to the brain. One of these strategies consists of linking the pharmacologically active substance to a molecular vector that acts as a molecular Trojan Horse and is capable of crossing the BBB using a receptor-mediated transcellular transport system of the brain capillary endothelial cells (BCECs). The transferrin receptor (TfR) is related to a transcytosis process in these cells, and the 8D3 monoclonal antibody (mAb), directed against the mouse TfR, is able to induce a receptor response. Thus, the 8D3 antibody could be a potential molecular Trojan Horse to transport pharmacologically active substances across the BBB. On these bases, a series of experiments were performed where the 8D3 antibody was conjugated to different cargoes, the resulting constructs were administered in vivo to mice, and the distribution and intracellular mechanisms that these constructs undergo at the BBB were
studied. Our results indicated a TfR-mediated and clathrin-dependent internalization
process by which the 8D3-cargo constructs enters the BCEC. The resulting endocytic
vesicles follow at least two different routes. On one hand, most vesicles enter intracellular
processes of vesicular fusion and rearrangement in which the cargo is guided to late
endosomes, multivesicular bodies or lysosomes. On the other hand, a small but not
negligible percentage of the vesicles follow a different route in which they fuse with the
abluminal membrane and open towards the basal lamina, indicating a potential route for
the delivery of therapeutic substances. In this route, however, the 8D3−cargo remain fixed
to the abluminal membrane, indicating that the 8D3 is maintained linked to the TfR, and
the cargo does not go beyond the basal membrane. Altogether, different optimization
approaches need to be developed for efficient drug delivery, but receptor-mediated
transport (RMT) continues to be one of the most promising strategies to overcome the
BBB.http://hdl.handle.net/2445/128124engFisiologia animalBarrera hematoencefàlicaAnimal physiologyBlood-brain barrierStudy of the transport of substances across the blood-brain barrier with the 8D3 anti-transferrin receptor antibody
oai:recercat.cat:2072/3497242020-02-14T15:06:23Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/128014The principal aim of this work was to optimize and apply a zebrafish experimental model for the screening of anti-inflammatory substances present in the Mediterranean diet. The zebrafish is an organism widely used in various fields of experimental biology. The inflammation is easily inducible, reproducible and visualized in their early stages of development. Specifically, the migration of neutrophils to the injured caudal fin, one of the first steps of the inflammatory response, is quantitatively measured by image analysis. The anti-inflammatory effect of natural compounds can be evaluated as a decrease of migration. Adverse effects triggered by inflammation are mainly mediated by reactive oxygen species. The anti-oxidant activity of compounds was evaluated in zebrafish embryo measuring their protective effect against tert-butyl hydroperoxide toxicity. Several phenolic compounds have been assayed. Our results showed that the compounds with the greatest decrease on neutrophil migration were chlorogenic acid and cyanidin. The activity of these two polyphenols was quite similar to that observed with anti-inflammatory drugs (indomethacin, piroxicam) and NADPH oxidase inhibitor compounds (dibenzoidolium, apocynin). The anti-inflammatory and the anti-oxidant activity of the assayed polyphenols did not show a clear correlation.http://hdl.handle.net/2445/128128engPeix zebraToxicologiaZebra danioToxicologyEvaluation of anti-inflammatory activity of food compounds using zebrafish
oai:recercat.cat:2072/3497252020-02-14T15:06:23Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/128014The presence of ascaridoid nematodes in commonly consumed fish constitutes an important health risk for humans as well as an economic problem for fisheries. Here, information is provided on the taxonomic status of the representative “anisakid-related” species of the families Anisakidae and Raphidascarididae. These parasites have a worldwide marine geographical distribution, mainly related to the presence of the vertebrate hosts involved in their life cycle. Morphological and molecular methods currently used for specific characterization of larval and adult nematode specimens are analysed and discussed. This study is focused on the taxonomy and parasite-host distribution of species of the genera Anisakis and Hysterothylacium from the North-East Atlantic Ocean and Mediterranean Sea regions.http://hdl.handle.net/2445/128131engNematodesPeixosBiogeografiaParasitologiaNematodesFishesBiogeographyParasitologyBiogeography of Anisakis (Anisakidae) and Hysterothylacium (Rhaphidascarididae) nematode species in consumed fish
oai:recercat.cat:2072/3497262020-02-14T15:06:24Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/128014The introduction of high performance thin-layer chromatography (HPTLC) for quality control of herbal products, using standardised methodology and system suitability tests for the qualification of the plates, has improved reproducibility. The use of intensity markers implemented by the Ph. Eur. improved the description and interpretation of the chromatograms. Quantitative information can be retrieved from the electronic images of the chromatograms and used for comprehensive HPTLC fingerprinting: a single HPTLC analysis gives information on identity, purity and content of an herbal drug/preparation/product, simplifying the quality control.http://hdl.handle.net/2445/128132engCromatografia de capa primaControl de qualitatPlantes medicinalsThin layer chromatographyQuality controlMedicinal plantsHigh performance thin-layer chromatography (HPTLC) in the quality control of herbal products
oai:recercat.cat:2072/2021622020-02-14T15:06:24Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32393The c-Jun N-terminal kinases (JNK) are members of the MAPK family and can be activated by different stimuli such as cellular stress, heat shock and ultra-violet irradiation. JNKs have different physiological functions and they have been linked to apoptosis in different cell types. Therefore, the JNK signalling pathway is an important target to prevent cell death. In the present chapter, the role of JNKs in neurodegenerative diseases will be discussed, as well as the pharmacological compounds that inhibit this signalling pathway as therapeutic intervention to prevent neuronal death.http://hdl.handle.net/2445/32186engFarmacologiaMalalties neurodegenerativesPharmacologyNeurodegenerative diseasesRole of JNK in neurodegenerative diseases
oai:recercat.cat:2072/3712872020-02-14T15:06:25Zhdl_2072_179329 am 3u dchttp://hdl.handle.net/2445/46988engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences III
oai:recercat.cat:2072/2198182020-02-14T15:06:25Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/46988Mimicking Nature, supramolecular chemistry represents the chemistry beyond the molecule, in view that intermolecular
interactions constitute the driving force for the preparation of molecular and supramolecular assemblies, using the chemical
information contained in molecular building blocks. Upon molecular recognition between discrete units, chemical processes
such as self-assembly and self-organisation start operating, and are the leading processes to build up supramolecular aggregates and materials. When those materials have dimensions on the
nanometric scale, a recently emerging scientific discipline is defined,
Nanoscience. Nanomaterials are promising tools for many applications, and their use in biomedical and clinical applications
defines the so-called Nanomedicine. In this review we present a few selected examples of nanomaterials designed for therapeutical purposes, emphasizing the importance of the preparation methodology in terms of their therapeutical use.http://hdl.handle.net/2445/46989engInvestigació farmacèuticaQuímica supramolecularNanomedicinaPharmaceutical researchSupramolecular chemistryNanomedicineSupramolecular chemistry for nanomedicine
oai:recercat.cat:2072/2198192020-02-14T15:06:26Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/46988Due to the increase of the incidence of fungal infections in humans and the limitations of the available antimycotic drugs, among which the emergence of resistant strains, there is a need for the discovery of new antifungal agents. Plants, especially those used in Traditional Medicine, linked to an unmatched chemical diversity, either as pure compounds or as plant extracts, provide unlimited opportunities for the development of new antifungals. In
recent years, compounds from different phytochemical groups have been described as having antifungal activity, including polyphenols, saponins, or peptides, among others, as well as
essential oils and their constituents. After screening of ethnopharmacologically selected plants, mainly from Latin-America, followed by bio-guided isolation, our group has
described the antifungal activity of different types of plant constituents, such as sesquiterpenes, triterpenes, flavonoids, lignans, fatty acids and essential oils.http://hdl.handle.net/2445/46991engInvestigació farmacèuticaMedicaments antifúngicsPlantes medicinalsPharmaceutical researchAntifungal agentsMedicinal plantsAntifungal compounds from plants
oai:recercat.cat:2072/3712882020-02-14T15:06:27Zhdl_2072_179329 am 3u dcReproducció del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=234Like in the three previous editions, this E-book compiles a series of
contributions in the multidisciplinary research arena of Pharmaceutical
Sciences. The E-book has been organized in 12 chapters, whose main topics
belong to the fields of pharmacology, physical chemistry, plant physiology,
microbiology, physiology, preventive medicine and public health, food
science, botany, clinical pharmacy and pharmacotherapy, organic
chemistry, biochemistry and molecular biology, and parasitology...http://hdl.handle.net/2445/63704engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences IV
oai:recercat.cat:2072/3712892020-02-14T15:06:27Zhdl_2072_179329 am 3u dcReproducció del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=249This E-book is the fifth volume of a series that compiles contributions
from different areas of the multidisciplinary field of Pharmaceutical
Sciences. The E-book consists of 11 chapters that cover the areas of
organic chemistry, health and environmental management, plant
physiology, food science, toxicology, botany, parasitology, physiology,
biochemistry and molecular biology, microbiology, and pharmacology.http://hdl.handle.net/2445/67430engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences V
oai:recercat.cat:2072/3712902020-02-14T15:06:27Zhdl_2072_179329 am 3u dcThis E-book is the sixth volume of a series that compiles contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences, particularly phisical chemistry, food science, toxicology, botany, biochemistry and molecular biology, preventive medicine and public health, pharmacology, physiology, microbiology, and parasitology.http://hdl.handle.net/2445/103042engInvestigació farmacéuticaPharmaceutical researchRecent Advances in Pharmaceutical Sciences VI
oai:recercat.cat:2072/3712912020-02-14T15:06:27Zhdl_2072_179329 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/103042In the last decade, a new family of synthetic psychostimulant drugs, under the name of cathinones, broke into the market. These drugs are mainly consumed by adolescents and young adults with recreational purposes, in most cases combined with alcoholic drinks. Although a number of works about new cathinones have been recently published, none explored the consequences of such combination. Because adolescence is a crucial period in brain development, we sought to study the effects of the combination of mephedrone plus ethanol in adolescent mice, focusing on psychostimulant and conditioning effects, as well as on neurotoxicity markers. Ethanol increased both locomotor activity and conditioned place preference (CPP) induced by mephedrone. RNA microarray assays after CPP test yielded significant alterations in neuronal plasticity-related genes and a key role of BDNF and dopamine D3 receptors in CPP acquisition was found. Ethanol potentiated the oxidative stress as well as the decreases in dopaminergic and serotonergic markers in frontal cortex and hippocampus respectively, after a binge treatment with mephedrone. Moreover, the drug combination impaired spatial learning and memory, as well as neurogenesis to a higher extent than mephedrone alone.http://hdl.handle.net/2445/104143engDrogues de dissenyConsum d'alcoholAdolescentsDesigner drugsDrinking of alcoholic beveragesTeenagersNeuropsychopharmacologic and neurotoxicologic effects of the combination of ethanol with mephedrone in adolescent mice