2024-03-28T13:44:16Zhttp://oai.recercat.cat/request
oai:recercat.cat:2072/2198142013-11-12T15:04:06Zhdl_2072_179321 am 3u dc2013-11-07T11:55:24ZStrategies that enhance fat degradation or reduce caloricfood intake could be considered therapeutic interventions to reduce notonly obesity, but also its associated disorders. The enzyme carnitinepalmitoyltransferase 1 (CPT1) is the critical rate-determining regulatorof fatty acid oxidation (FAO) and might play a key role in increasingenergy expenditure and controlling food intake. Our group has shownthat mice overexpressing CPT1 in liver are protected from weight gain,the development of obesity and insulin resistance. Regarding foodintake control, we observed that the pharmacological inhibition ofCPT1 in rat hypothalamus decreased food intake and body weight.This suggests that modulation of CPT1 activity and the oxidation offatty acids in various tissues can be crucial for the potential treatmentof obesity and associated pathologies.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988http://hdl.handle.net/2445/46996engInvestigació farmacèuticaObesitatPharmaceutical researchObesityNew strategies in the modulation of fatty acid oxidation as a treatment for obesity
oai:recercat.cat:2072/1795232017-05-08T23:56:41Zhdl_2072_179321 am 3u dcPodeu consultar el llibre complet a: http://www.trnres.com/ebookcontents.php?id=149The aim of this work was to design a novel strategy to detect new targets for anticancer treatments. The rationale was to build Biological Association Networks from differentially expressed genes in drug-resistant cells to identify important nodes within the Networks. These nodes may represent putative targets to attack in cancer therapy, as a way to destabilize the gene network developed by the resistant cells to escape from the drug pressure. As a model we used cells resistant to methotrexate (MTX), an inhibitor of DHFR. Selected node-genes were analyzed at the transcriptional level and from a genotypic point of view. In colon cancer cells, DHFR, the AKR1 family, PKC¿, S100A4, DKK1, and CAV1 were overexpressed while E-cadherin was lost. In breast cancer cells, the UGT1A family was overexpressed, whereas EEF1A1 was overexpressed in pancreatic cells. Interference RNAs directed against these targets sensitized cells towards MTX.http://hdl.handle.net/2445/21368engCàncerQuimioteràpiaFarmacogenèticaCancerChemotherapyPharmacogeneticsGeneration of biological association networks: A novel strategy to detect new targets in cancer therapy
oai:recercat.cat:2072/3712822020-02-14T15:04:55Zhdl_2072_179321 am 3u dchttp://hdl.handle.net/2445/32393engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences II
oai:recercat.cat:2072/3712832020-02-14T15:04:56Zhdl_2072_179321 am 3u dchttp://hdl.handle.net/2445/46988engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences III