2024-03-28T17:40:45Zhttp://oai.recercat.cat/request
oai:recercat.cat:2072/1795172013-11-12T15:03:39Zhdl_2072_179319 am 3u dc2012-01-27T11:48:26ZThe genus Artemisia is one of the largest of the Asteraceae family, with more than 500 species. It is widely distributed mainly across the Northern Hemisphere, being profusely represented in the Old World, with a great centre of diversification in Asia, and also reaching the New World. The evolution of this genus has been deeply studied using different approaches, and polyploidy has been found to perform an important role leading to speciation processes. Karyological, molecular cytogenetic and phylogenetic data have been compiled in the present review to provide a genomic characterization throughout some complexes within the genus.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392http://hdl.handle.net/2445/21363engArtemísiaEvolució vegetalCitogenèticaArtemisiaPlant evolutionCytogeneticsArtemisia (Asteraceae): Understanding its evolution using cytogenetic and molecular systematic tools, with emphasis on subgenus Dracunculus
oai:recercat.cat:2072/2184572013-11-12T15:03:39Zhdl_2072_179319 am 3u dc2013-10-15T22:15:16ZPlant cell cultures constitute a promise for the production of a high number of phytochemicals, although the majority ofbioprocesses that have been developed so far have not resultedcommercially successful. An overview indicates that most of theresearch carried out until now is of the empirical type. For this reason,there is a need for a rational approach to the molecular and cellularbasis of metabolic pathways and their regulation in order to stimulatefuture advances.The empirical investigations are based on the optimization of theculture system, exclusively considering input factors such as theselection of cellular lines, type and parameters of culture, bioreactordesign and elicitor addition, and output factors such as cellular growth,the uptake system of nutrients, production and yield. In a rationalapproach towards the elucidation of taxol and related taxaneproduction, our group has studied the relationship between the taxaneprofile and production and the expression of genes codifying forenzymes that participate in early, intermediate and late steps of theirbiosynthesis in elicited Taxus spp cell cultures. Our results show that elicitors induce a dramatic reprogramming of gene expression in Taxus cell cultures, whichlikely accounts for the enhanced production of taxol and related taxanes and we have alsodetermined some genes that control the main flux limiting steps. The application ofmetabolic engineering techniques for the production of taxol and taxanes of interest is also discussed.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988http://hdl.handle.net/2445/46997engInvestigació farmacèuticaPharmaceutical researchBiotechnological production of taxanes: a molecular approach
oai:recercat.cat:2072/2184582013-11-12T15:03:40Zhdl_2072_179319 am 3u dc2013-10-15T22:15:17ZThe precise generic delimitation of Aliella andPhagnalon, and their closest relatives within the Gnaphalieae are discussed in this review. Among the main results obtained, wehave found that the genera Aliella and Phagnalon are nested withinthe “Relhania clade” and Anisothrix, Athrixia and Pentatrichia aretheir closest relatives. Macowania is also part of the “Relhaniaclade”, whereas the subtribal affinities of Philyrophyllum liewithin the “crown radiation clade”. The monophyly of Aliellaand Phagnalon is not supported statistically. In addition,Aliella appears to be paraphylethic in most of the analysesperformed. The resulting phylogeny suggests an African origin forthe ancestor of Aliella and Phagnalon and identifies three mainclades within Phagnalon that constitute the following naturalgroups on a geographic basis: (1) the Irano-Turanian clade; (2) the Mediterranean-Macaronesian clade; and (3) the Yemen-Ethiopian clade. Some endemics to Yemen and Ethiopia appeared merged in the Mediterranean-Macaronesian clade, providing new evidence of the phytogeographical links betweenMacaronesia, Eastern Africa and Southern Arabia. Incongruities between thechloroplast and nuclear molecular data and the lack of resolution in some clades mayindicate that hybridization could have played an important role in the evolution anddiversification of both Phagnalon and Aliella.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988http://hdl.handle.net/2445/46999engInvestigació farmacèuticaCompostesPharmaceutical researchCompositaePhylogenetic studies in Gnaphalieae (Compositae): The genera Phagnalon Cass. and Aliella Qaiser & Lack
oai:recercat.cat:2072/2184592013-11-12T15:03:40Zhdl_2072_179319 am 3u dc2013-10-15T22:15:17ZReclamation and reuse of wastewater require the use of tools that minimize risks to health and natural ecosystems. There are various types of such tools, among which HACCP (hazardanalysis and critical control points) and barrier systems are gainingimportance. The research reported here aims to determine andevaluate the most efficient combinations of different treatmentsystems—barriers—for the reclamation of secondary effluentsfrom urban sewage treatment plants, and for obtaining water ofsufficient quality for reuse in accordance with existing legislation,in which water disinfection has become one of the keys tocompliance. Several conventional and non-conventional reclamationtechnologies are evaluated. The results lead us to recommendtreatment lines for the different reclaimed water uses established inthe Spanish legislation.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988http://hdl.handle.net/2445/47002engInvestigació farmacèuticaReutilització de l'aiguaPharmaceutical researchWater reuseEvaluation of reclamation technologies for wastewater reuse
oai:recercat.cat:2072/2021562013-11-12T15:03:41Zhdl_2072_179319 am 3u dc2012-10-04T22:12:37ZPolyamines (PAs) are small polycationic compounds present in all living organisms. Compelling evidences indicate a role for PAs in plant protection against stress. During the recent years, genetic, molecular and ‘omic’ approaches have been undertaken to unravel the role of PAs in stress signaling. Overall, results point to intricate relationships between PAs, stress hormone pathways and ROS signaling. Such cross-regulations condition stress signaling through the modulation of abscisic acid (ABA) and ROS amplification-loops. In this chapter we compile our recent findings which elucidate molecular mechanisms and signalingpathways by which PAs contribute to stress protection in plants.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393http://hdl.handle.net/2445/32188engFarmacologiaPoliaminesMetabolisme de les plantesPharmacologyPolyaminesPlant metabolismPolyamine metabolism and signaling in plant abiotic stress protection
oai:recercat.cat:2072/2479992015-03-24T23:14:06Zhdl_2072_179319 am 3u dcThis study reveals that a successful ethnobotanical survey can take place still nowadays, even close to one of the hotspots of tourism in the Mediterranean coast. This is the first approach in this field entirely based on interviews with local people in Mallorca. An amount of 235 informants has been inquired from all the 53 municipalities of the island. The data collected have been analyzed from the botanical and ethnographical points of view, and managed using the online platform of our research team (details at www.etnobiofic.cat). The Mallorcan ethnopharmacopoeia includes 255 plant taxa referring more than 150 medicinal use categories. Ethnomedical queries as the one here presented contribute to the knowledge of the traditional use of plants of the island and appreciate the benefits of this knowledge, applied to the present and future of its society.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704http://hdl.handle.net/2445/64325engEtnobotànicaMedicina tradicionalMallorca (Illes Balears)EthnobotanyTraditional medicineMajorca (Balearic Islands)Back to the island of calm: Mallorcan human traditional medicine and ethnobotany
oai:recercat.cat:2072/1795182015-11-09T23:13:50Zhdl_2072_179319 am 3u dcChlorinated solvents such as trichloroethene (TCE) and tetrachloroethene (PCE) form a class of dense non-aqueous phase liquid (DNAPL) compounds that cause a persistent environmental contamination that is difficult to investigate and challenging to remediate. The use of vegetation to enhance degradation by soil microorganisms of chlorinated solvents in soil-groundwater systems (phyto and rhizo-degradation) has been receiving attention since the 90¿ as an attractive low-cost alternative. Remediation strategies must be site-specific, with separate approaches often warranted for the DNAPL source zone and its associated aqueous phase plume. It has been suggested that possible mechanisms for the enhanced bioremediation of TCE in the rhizosphere are excretion of phenolic compounds in root exudates and plant mycorrhization.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392http://hdl.handle.net/2445/21372engSòlsBiodegradacióSoilsBiodegradactionBiological remediation approach involving soils and groundwaters polluted with chlorinated solvents in a Mediterranean context
oai:recercat.cat:2072/2021572015-11-20T08:47:17Zhdl_2072_179319 am 3u dcGreen chemistry plays a very important role in the sustainable development, seeking to reduce and prevent pollution at its source, minimizing the hazard and maximizing the efficiency of the chemical processes. Ionic liquids (ILs) are a new generationof chemicals that have a great potential for contributing to the greenness of chemical processes and developing new applications,both being of interest for the pharmaceutical industry. This workdeals with the development of ILs as greener alternatives for some of the processes within the frame of green chemistry. It focuses on the environmental impact of the ILs, their ecotoxicity and potentialbiodegradability, compiling results of different ecotoxicological studies. ILs have the reputation of being “green” chemicals, but not all of them can pass favourably the tests evaluating their environmental effects.Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393http://hdl.handle.net/2445/32193engFarmacologiaProductes químicsToxicologiaBiodegradacióPharmacologyChemical productsToxicologyBiodegradationGreen chemistry: ecotoxicity and biodegradability of ionic liquids
oai:recercat.cat:2072/2021552016-03-15T23:48:10Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32393Microorganisms group themselves into assemblies known as communities or biofilms, which are associated with surfaces. A matrix of self-segregated polymeric substances enhances their attachment. Communication between bacterial cells involves the production and detection of diffusible signal molecules, known as quorum sensing, which is an important regulatory mechanism of biofilm strategies. Biofilms thrive everywhere; in subaerial surfaces they can be driven by sunlight, with photosynthesizing components. A special case is those which colonize works of art, forming patinas and becoming involved in the degradation of colonized substrata. Knowledge of threedimensional structure of the biofilm and the distribution of species concerned is crucial for managing and preventing uncontrolled colonization and for preserving cultural heritage sites. This paper describes their role in this degradation, some examples of biofilms and their resilience mechanisms. The methods used in their study when growing in monuments and caves are also discussed.http://hdl.handle.net/2445/32185engFarmacologiaEcologia microbianaGeomaterialsPharmacologyMicrobial ecologyGeomaterialsBiofilms on rocks
oai:recercat.cat:2072/2652542016-07-05T08:36:51Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32393Biosurfactants (BS) are a structurally diverse group of surface-active substances produced by microorganisms. Interest in
BS production has markedly increased during the past decade, although large-scale production has not been possible because of
low production yields and high total costs. At present, BS have gained importance in environmental applications, while new
applications in the pharmaceutical, biomedical, cosmetic and food
industry, with a high added value, are still developing. This article describes classical and new BS producer bacteria together with
their new BS applications. With these specialized and costeffective
applications, BS can be considered as an interesting option for the near future.http://hdl.handle.net/2445/32196engFarmacologiaAgents tensioactiusPharmacologySurface active agentsAdvances in the research of new biosurfactants and their potential use in the biomedical and pharmaceutical industry
oai:recercat.cat:2072/2652552016-07-05T08:36:51Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32393The relevancy of parasites as potential indicators of environmental quality has been increasing over the last years, mostly due to the variety of ways in which they respond to anthropogenic pollution. The use of fish parasites as bioindicators of heavy metal pollution in aquatic ecosystems has been widely studied. However, little information concerning terrestrial habitats is presently available. In fact, in the last two decades several studies have been performed worldwide in different habitats and/or conditions (theoretically both in polluted and unpolluted terrestrial
ecosystems, but mainly in aquatic ecosystems) in order to investigate heavy metal pollution using parasitological models. Different groups of vertebrates (mainly fish, mammals and birds) and several parasitological models have been tested involving acanthocephalans mostly, but also cestodes and nematodes. It is not the aim of this chapter to do a complete revision of the available
data concerning this subject. Instead, we emphasize some general aspects and compile a mini-review of the work performed in this field by our research group. The results obtained until now allow confirming several parasitic models as promising bioindicator systems to evaluate environmental cadmium and mainly lead pollution in terrestrial non-urban habitats, as it was already demonstrated for aquatic ecosystems. The present knowledge also allows confirming that parasites can reveal environmental impact. Environmental parasitology is an interdisciplinary field, which needs simultaneous expertise from toxicology, environmental chemistry and parasitology. Furthermore, environmental parasitology should be taken into account in order to increase the efficiency of environmental monitoring programs.http://hdl.handle.net/2445/32204engFarmacologiaMetalls pesantsIndicadors biològicsPharmacologyHeavy metalsIndicators (Biology)Heavy metal accumulation by intestinal helminths of vertebrates
oai:recercat.cat:2072/2652562016-07-05T08:36:51Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/46988Although several approaches have been attempted, the estimation of recombination frequencies in natural populations of
bacteria remains challenging. Previous studies have demonstrated a
wide variety of situations among bacterial species, ranging from the
clonal diversification of Salmonella or Escherichia coli, which are
mainly due to mutation, to the frequent recombination found in
Neisseria gonorrhoeae or Helicobacter pylori. Most of the population
studies done with bacterial species suggest that recombination occurs
in nature but that it is infrequent compared to mutation. Consequently,
bacterial populations consist largely of independent clonal lineages.
Our research suggests little or null influence of recombination in the
genetic structure of "Aeromonas hydrophila Species Complex", despite the presence of some strains with recombinant gene fragments.http://hdl.handle.net/2445/47003engInvestigació farmacèuticaBacteris patògensRecombinació genèticaPharmaceutical researchPathogenic bacteriaGenetic recombinationThe effect of recombination in Aeromonas
oai:recercat.cat:2072/2652572016-07-05T08:36:51Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/46988The entomological and canine leishmaniosis surveys
carried out in the northwest of Catalonia and in Andorra in the
context of the European project Emerging Diseases in a changing European eNvironment (EDEN) are summarized. The aim of the study was to obtain data on the presence of leishmaniosis in these areas and the spatial distribution of their vectors.http://hdl.handle.net/2445/47004engInvestigació farmacèuticaLeishmaniosiPharmaceutical researchLeishmaniasisIs leishmaniosis spreading to northern areas of the Iberian Peninsula? The examples of Lleida (NE Spain) and Andorra
oai:recercat.cat:2072/2652582016-07-05T08:36:51Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/63704Many Gram-negative, cold-adapted bacteria from the Antarctic environment produce large amounts of extracellular matter with potential biotechnological applications. Transmission electron microscopy (TEM) analysis after high-pressure freezing and freeze substitution (HPF-FS) showed that this extracellular matter is structurally complex, appearing around cells as a netlike mesh, and composed of an exopolymeric substance (EPS) containing large numbers of outer membrane vesicles (OMVs). Isolation, purification and protein profiling via 1D SDS-PAGE confirmed the outer membrane origin of these Antarctic bacteria OMVs. In an initial attempt to elucidate the role of OMVs in cold-adapted strains of Gram-negative bacteria, a proteomic analysis demonstrated that they were highly enriched in outer membrane proteins and periplasmic proteins associated with nutrient processing and transport, suggesting that the OMVs may be involved in nutrient sensing and bacterial survival. OMVs from Gram-negative bacteria are known to play a role in lateral DNA transfer, but the presence of DNA in these vesicles has remained difficult to explain. A structural study of Shewanella vesiculosa M7T using TEM and Cryo-TEM revealed that this Antarctic Gram-negative bacterium naturally releases conventional one-bilayer OMVs, together with a more complex type of OMV, previously undescribed, which on formation drags along inner membrane and cytoplasmic content and can therefore also entrap DNA.http://hdl.handle.net/2445/63972engBacterisResistència al fredAntàrtidaMicrobiologiaBacteriaCold adaptationAntarcticaMicrobiologyOuter membrane vesicles from cold-adapted antarctic bacteria
oai:recercat.cat:2072/2652592016-07-05T08:36:52Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/63704Leishmaniasis comprises a group of diseases caused by protozoa of the genus Leishmania and has two basic clinical forms, visceral Leishmaniasis and cutaneous Leishmaniasis. The clinical features of Leishmaniasis depend on the species of Leishmania, the interaction between host and parasite and the immune response. This work focuses on cutaneous leishmaniosis because although it is not a deadly disease it results in significant scars and facial disfigurements, thus being clinically important. Furthermore, the first-line treatment consists of intravenous or intramuscular administration of intralesional pentavalent antimonials, which are highly toxic, making hospitalization of patients compulsory during treatment, with the associated financial costs. Herein, we review studies on drugs and treatments with fewer side effects and easier routes of administration such as topical administration. Recent research shows that the topical route of administration holds promise for the future treatment of cutaneous leishmaniosis.http://hdl.handle.net/2445/64369engLeishmaniosiMedicamentsLeishmaniasisDrugsReview and new therapeutic alternatives for the treatment of cutaneous Leishmaniasis
oai:recercat.cat:2072/2687242016-12-06T01:22:00Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/103042Here we present an overview on the results of eight years of research line devoted to the organisation, expression and evolution of rRNA genes in plant genomes. We describe how we discovered a new rDNA arrangement in genus Artemisia, which includes all rRNA genes in a single unit (L-type). This was the first time that such organisation was found in seed plants. We further explored family Asteraceae in depth, to which Artemisia belongs, to find that the L-type arrangement may be present in about 25% of its species. Later on we move to gymnosperms to describe the landscape of rRNA arrangements in a representative sample of its diversity. We assess the expression rate of the L-type rRNA in several L-type species, which is comparable to that of species with separated arrangement of rRNA genes (S-type). Finally, we present the resource www.plantrdnadatabase.com which includes information on type of rDNA arrangement, number and position of rDNA loci in plants.http://hdl.handle.net/2445/103608engGensGenòmicaPlantesGenesGenomicsPlantsOrganisation, expression and evolution of rRNA genes in plant genomes
oai:recercat.cat:2072/2652512017-07-18T08:09:05Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32392Lipoxygenases are non-heme iron enzymes essential in eukaryotes, where they catalyze the formation of the fatty acid hydroperoxides that are required by a large diversity of biological and pathological processes. In prokaryotes, most of them totally lacking in polyunsaturated fatty acids, the possible biological roles of
lipoxygenases have remained obscure. In this study, it is reported the crystallization of a lipoxygenase of Pseudomonas aeruginosa (Pa_LOX), the first from a prokaryote. High resolution data has been acquired which is expected to yield structural clues to the questions adressed. Besides, a preliminar phylogenetic analysis using 14 sequences has confirmed the existence of this subfamily of bacterial lipoxygenases, on one side, and a greater diversity than in the corresponding eukaryotic ones, on the other. Finally, an evolutionary study of bacterial
lipoxygenases on the same set of lipoxygenases, show a selection pressure of a basically purifying or neutral character except for a single aminoacid, which would have been selected after a positive selection event.http://hdl.handle.net/2445/21364engPseudomonasEnginyeria genèticaPseudomonasGenetic engineeringCrystallization and resolution of the lipoxygenase of Pseudomonas aeruginosa 42A2 and phylogenetic study of the subfamilies of the lipoxygenases
oai:recercat.cat:2072/1795192018-04-26T05:33:57Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/32392The Amaryllidaceae alkaloids represent a large (over 300 alkaloids have been isolated) and still expanding group of biogenetically related isoquinoline alkaloids that are found exclusively in plants belonging to this family. In spite of their great variety of pharmacological and/or biological properties, only galanthamine is used therapeutically. First isolated from Galanthus species, this alkaloid is a long-acting, selective, reversible and competitive inhibitor of acetylcholinesterase, and is used for the treatment of Alzheimer¿s disease. Other Amaryllidaceae alkaloids of pharmacological interest will also be described in this chapter.http://hdl.handle.net/2445/21374engAlcaloidesAmaril·lidàciesAlkaloidAmaryllidaceaeChemical and biological aspects of Amaryllidaceae alkaloids
oai:recercat.cat:2072/3712782020-02-14T15:04:40Zhdl_2072_179319 am 3u dchttp://hdl.handle.net/2445/32392engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences
oai:recercat.cat:2072/3712792020-02-14T15:04:41Zhdl_2072_179319 am 3u dchttp://hdl.handle.net/2445/32393engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences II
oai:recercat.cat:2072/3712802020-02-14T15:04:42Zhdl_2072_179319 am 3u dchttp://hdl.handle.net/2445/46988engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences III
oai:recercat.cat:2072/2551752020-02-14T15:04:42Zhdl_2072_179319 am 3u dcReproducció del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=249This E-book is the fifth volume of a series that compiles contributions
from different areas of the multidisciplinary field of Pharmaceutical
Sciences. The E-book consists of 11 chapters that cover the areas of
organic chemistry, health and environmental management, plant
physiology, food science, toxicology, botany, parasitology, physiology,
biochemistry and molecular biology, microbiology, and pharmacology.http://hdl.handle.net/2445/67430engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences V
oai:recercat.cat:2072/3712812020-02-14T15:04:42Zhdl_2072_179319 am 3u dcThis E-book is the sixth volume of a series that compiles contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences, particularly phisical chemistry, food science, toxicology, botany, biochemistry and molecular biology, preventive medicine and public health, pharmacology, physiology, microbiology, and parasitology.http://hdl.handle.net/2445/103042engInvestigació farmacéuticaPharmaceutical researchRecent Advances in Pharmaceutical Sciences VI
oai:recercat.cat:2072/3304632020-02-14T15:04:43Zhdl_2072_179319 am 3u dcThe E-book series Recent Advances in Pharmaceutical Sciences reports research contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences. This seventh volume consists of nine chapters, mainly dealing with the fields of botany, physiology, food
science, biochemistry & molecular biology, plant physiology, microbiology, parasitology, pharmacology, and medicinal chemistry.http://hdl.handle.net/2445/120717engInvestigació farmacèuticaPharmaceutical researchRecent advances in pharmaceutical sciences VII
oai:recercat.cat:2072/3497202020-02-14T15:04:43Zhdl_2072_179319 am 3u dcPodeu consultar el llibre complet a: http://hdl.handle.net/2445/128014The presence of ascaridoid nematodes in commonly consumed fish constitutes an important health risk for humans as well as an economic problem for fisheries. Here, information is provided on the taxonomic status of the representative “anisakid-related” species of the families Anisakidae and Raphidascarididae. These parasites have a worldwide marine geographical distribution, mainly related to the presence of the vertebrate hosts involved in their life cycle. Morphological and molecular methods currently used for specific characterization of larval and adult nematode specimens are analysed and discussed. This study is focused on the taxonomy and parasite-host distribution of species of the genera Anisakis and Hysterothylacium from the North-East Atlantic Ocean and Mediterranean Sea regions.http://hdl.handle.net/2445/128131engNematodesPeixosBiogeografiaParasitologiaNematodesFishesBiogeographyParasitologyBiogeography of Anisakis (Anisakidae) and Hysterothylacium (Rhaphidascarididae) nematode species in consumed fish